The Conservatory of Music was opened in 1843 in the courtyard of the Old Gewandhaus at Neumarkt. Today, the location houses the Städtisches Kaufhaus.
The subjects initially only included piano, violin, organ, voice and composition. It was only in the course of the 19th century that the range of courses was extended to include the most common orchestral instruments. The conservatory quickly gained international fame, partially through its close cooperation with the Gewandhaus Orchestra. Students, both men and women, from numerous European countries and later from the USA came to study here. Particularly well-known students of the first decades were Edvard Grieg, who stayed in Leipzig from 1858 to 1862, and Leos Janacek, who attended the conservatory from 1879 to 1880. In 1887 the conservatory moved into its present building at Grassistraße 8 in the Musikviertel, today's University of Music and Theatre.